The obvious answer would be Black & White and its sequel, which for many is the definitive god game. You’re an untouchable god interacting with your world and physically manipulating it with your hand, but you also have a giant animal familiar that you raise to also interact with the people. You create miracles and either help or terrorize the population into following you. Not much combat if that’s what you’re looking for, but it’s a unique game that unfortunately has not seen a worthy successor in 20+ years.
I don’t even remember the last time Stephanie Sterling did anything like this, so it was just a weird blip. Not that she doesn’t goof a bunch. Still a great channel to stay up to date on the things that actually matter in the games industry instead of the usual hype machine shit. The only thing I don’t care for on the show is the wrestling stuff and when the editor does some schtick.